Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (546)
Related Products (546)
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15(R)-Prostaglandin I2 sodium
0 ImagesCat. No.: HY-W747129Synonyms: 15(R)-PGI2 sodium15(R)-Prostaglandin I2 (15(R)-PGI2) sodium is a 15(R)-stereoisomer of Epoprostenol (Prostaglandin I2) sodium (HY-A0126A).
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cis-Cyclooctene-amine
0 ImagesCat. No.: HY-141176Bcis-Cyclooctene-amine is the cis isomer of TCO-amine (HY-141176). TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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(S)-Hydroxychloroquine sulfate
0 ImagesCat. No.: HY-145530CAS No.: 155204-09-4Synonyms: (S)-HCQ sulfate(S)-Hydroxychloroquine ((S)-HCQ) sulfate is an isomer of Hydroxychloroquine (HY-W031727). (S)-Hydroxychloroquine sulfate (2.5-20 mg/mL) reduces the rate of insulin degradation in liver homogenates isolated from non-diabetic and diabetic rats. Formulations containing Hydroxychloroquine have been used in the study of malaria, rheumatoid arthritis, and systemic lupus erythematosus.
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15(R),19(R)-Hydroxy prostaglandin E1
0 ImagesCat. No.: HY-172572CAS No.: 55123-67-6Synonyms: 15(R),19(R)-Hydroxy PGE115(R),19(R)-Hydroxy prostaglandin E1 is a dihydroxy metabolite/stereoisomer of Prostaglandin E1 (HY-B0131). 15(R),19(R)-Hydroxy prostaglandin E1 is found in the semen of some mammals, especially primates.
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cis-Cyclooctene-amine hydrochloride
0 ImagesCat. No.: HY-141176CPurity: 98.61%cis-Cyclooctene-amine hydrochloride is the cis isomer of TCO-amine hydrochloride (HY-141176A). TCO-amine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine hydrochloride is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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(R)-GSK-F1
0 ImagesCat. No.: HY-100603BCAS No.: 1384097-28-2
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(3S,5S)-Fluvastatin sodium
0 ImagesCat. No.: HY-Z5058ACAS No.: 194935-01-8(3S,5S)-Fluvastatin sodium is the isomer of Fluvastatin sodium (HY-14664A). Fluvastatin sodium is a first fully synthetic, competitive HMG-CoA reductase inhibitor.
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rel-Avibactam sodium
0 ImagesCat. No.: HY-14879DCAS No.: 396731-20-7Synonyms: rel-NXL-104; rel-AVE1330Arel-Avibactam sodium (rel-NXL-104) is an isomer of Avibactam (HY-14879). Avibactam is a β-lactamase inhibitor with an IC50 of 8 nM against TEM-1 β-lactamase and an IC50 of 80 nM against P99 β-lactamase. Avibactam exhibits no significant intrinsic antibacterial activity when used alone. Avibactam restores the activity of Ceftazidime (HY-B0593) against β-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Avibactam does not enhance the activity of Ceftazidime against Acinetobacter spp., Burkholderia spp., or most anaerobic Gram-negative bacilli. Avibactam is used in research related to Gram-negative bacterial infections.
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(±) Anabasine (Standard)
0 Images(±) Anabasine (Standard) is the analytical standard of (±) Anabasine (HY-W052144). This product is intended for research and analytical applications. (±) Anabasine is the racemic form of Anabasine (HY-B1532). (±) Anabasine stimulates the release of [3H]-Dopamine from mouse striatal synaptosomes. (±) Anabasine inhibits the high-affinity binding of [3H]-S-(-)-Nicotine to the striatal membrane. Anabasine is an agonist of α7nAChR and possesses anti-inflammatory and insecticidal activities.
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meso-Astaxanthin
0 ImagesCat. No.: HY-N13470CAS No.: 71772-51-5meso-Astaxanthin is a natural stereoisomer of Astaxanthin (HY-B2163) with antioxidant activity and is found in a variety of aquatic animals. meso-Astaxanthin binds to human serum albumin in a monomeric form at a stoichiometric ratio; at low ligand-to-protein ratios, human serum albumin acts as a chiral template for supramolecular assembly at higher ratios. meso-Astaxanthin directly scavenges superoxide anions. meso-Astaxanthin can be used in the research of myocardial ischemia-reperfusion injury.
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rel-Avibactam
0 ImagesCat. No.: HY-187660CAS No.: 396731-14-9Synonyms: rel-NXL-104 free acid; rel-AVE1330A free acidrel-Avibactam (rel-NXL-104 free acid) is an isomer of Avibactam (HY-14879). Avibactam is a β-lactamase inhibitor with an IC50 of 8 nM against TEM-1 β-lactamase and an IC50 of 80 nM against P99 β-lactamase. Avibactam exhibits no significant intrinsic antibacterial activity when used alone. Avibactam restores the activity of Ceftazidime (HY-B0593) against β-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Avibactam does not enhance the activity of Ceftazidime against Acinetobacter spp., Burkholderia spp., or most anaerobic Gram-negative bacilli. Avibactam is used in research related to Gram-negative bacterial infections.
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Oxiran-2-ylmethanol-d5
0 ImagesCat. No.: HY-Y1010SCAS No.: 1246819-20-4Synonyms: Glycidol-d5Oxiran-2-ylmethanol-d5 is the deuterium labeled Oxiran-2-ylmethanol (Glycidol) (HY-Y1010). Oxiran-2-ylmethanol is an ester product. Oxiran-2-ylmethanol induces base pair point mutations in bacterial strains and structural chromosome aberrations in cultured cells. Oxiran-2-ylmethanol forms N-(2,3-dihydroxypropyl)valine hemoglobin adducts. Oxiran-2-ylmethanol acts as an animal carcinogen but does not significantly induce micronucleated immature erythrocytes in animal bone marrow. Oxiran-2-ylmethanol enables anionic polymerization to produce linear poly(glycidol). Oxiran-2-ylmethanol can be used for cancer-related research.
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(R,R)-Voriconazole
0 ImagesCat. No.: HY-76200CCAS No.: 239807-03-5Synonyms: (R,R)-UK-109496(R,R)-Voriconazole ((R,R)-UK-109496) is an enantiomer of Voriconazole (HY-76200). Voriconazole (UK-109496) is a second-generation broad-spectrum triazole antifungal compound that inhibits the biosynthesis of fungal ergosterol. Voriconazole exerts its antifungal activity by inhibiting the 14-α-lanosterol demethylation mediated by fungal cytochrome P450 enzymes. Voriconazole exhibits blood-brain barrier permeability.
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Golgicide A-1 (Standard)
0 ImagesCat. No.: HY-100540CRCAS No.: 1394285-49-4Synonyms: GCA-1 (Standard)Golgicide A-1 (Standard) is the analytical standard of Golgicide A-1 (HY-100540C). This product is intended for research and analytical applications. Golgicide A-1 (GCA-1) is a less active cis-diastereomer of Golgicide A (GCA). Golgicide A-1 weakly inhibits mosquito reproduction.
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2,2'-Methylenediphenyl diisocyanate
0 Images2,2'-Methylenediphenyl diisocyanate (2,2′-MDI) is a sensitizer and an isomer of methylenediphenyl diisocyanate (MDI). 2,2'-Methylenediphenyl diisocyanate induces contact sensitization upon skin contact. 2,2'-Methylenediphenyl diisocyanate is used in studies of allergic contact dermatitis.
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(-)-Chloroquine
0 ImagesCat. No.: HY-W614112CAS No.: 58175-87-4(-)-Chloroquine is a chloroquine enantiomer.
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3'-(2-Fluorophenyl) ezetimibe
0 ImagesCat. No.: HY-Z3151CAS No.: 1798008-25-93'-(2-Fluorophenyl) ezetimibe is an isomer of the cholesterol transport inhibitor Ezetimibe (HY-17376).
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(Z)-Rilpivirine
0 ImagesCat. No.: HY-167642CAS No.: 500287-94-5Synonyms: (Z)-R278474; (Z)-TMC278; (Z)-DB08864(Z)-Rilpivirine ((Z)-R278474) is the (Z)-isomer of Rilpivirine (HY-10574). Rilpivirine is an effective and selective diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It exhibits potent antiviral activity against both wild-type HIV (EC50 = 0.4 nM) and mutant strains (EC50 = 0.1-2.0 nM).
